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Cancer specialists have hailed a ‘landmark moment’ for treatment after doctors bathed two patients’ livers with chemotherapy drugs.It is the first time that patients in the UK have received the targeted chemotherapy treatment on just one organ.

Doctors at Southampton General Hospital who pioneered the treatment say the technique could reduce side-effects by limiting the exposure of healthy tissue to the drugs.  This means higher doses could be given without causing damage to the patient. Dr Brian Stedman, a consultant interventional radiologist, has performed the 60-minute treatment on two patients.  The liver was separated using two balloons to divert the blood supply past the organ.

Following the treatment, known as chemosaturation therapy or percutaneous hepatic perfusion (PHP), the blood from the liver was drained from the patient and processed through a filtration machine to reduce toxicity before it was returned to the patient via the jugular vein.

Results of a recent study in the US showed patients who received PHP survived five times longer before the disease – metastatic melanoma – progressed than those who had standard chemotherapy.

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