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Charles West
Patients with complex cancers of the abdomen and pelvis which were previously deemed inoperable are now surviving long-term thanks to developments in surgical techniques and expertise.

Research published in the journal Cancers and part-funded by PLANETS Cancer Charity, showed patients undergoing high-complexity pelvic exenteration (PE) surgery can expect similar survival outcomes to those with less advanced tumours.

Around 4,000 patients in the UK require treatment for advanced pelvic cancers every year but PE is often ruled out due to potential damage to bones and major blood vessels.

The study, led by Charles West (pictured), a colorectal surgery research fellow at the University of Southampton and University Hospital Southampton, reviewed 319 cases of PE and found that, where clinicians do proceed, success rates are high.

It found that, even in the most complex cases requiring removal of pelvic bones or major blood vessels, five-year survival rates remained around 71% and median survival for patients undergoing high-complexity PE was 9.8 years compared to 10.5 years for conventional PE.

The study also looked at patients’ quality of life and demonstrated that, despite the challenges of recovery and complications from such extensive surgery, patients did not regret their decisions and had a good quality of life at 12 months.

“This study challenges the idea that more extensive tumors are untreatable,” explained Mr West. “It shows that, with the right surgical expertise, even the most complex cases can have similar survival rates and quality of life outcomes to those with less advanced disease.

“We hope the growing body of evidence for intervention in highly complex abdominal and pelvic cancers will lead to more patients being able to benefit.”

Neil Pearce, co-founder and chair of PLANETS Cancer Charity, said: “This research highlights the importance of pushing the boundaries of cancer treatment.

“By funding studies like this, PLANETS is helping to build the evidence that will improve outcomes for patients with the most complex and difficult-to-treat cancers.

“The findings will be vital in shaping future treatment pathways and ensuring more patients have access to potentially life-saving surgery.”

PLANETS helps patients with pancreatic, liver, colorectal, abdominal (oesophageal and gastric) and neuroendocrine cancer by funding patient support groups and other initiatives, innovative treatments and research.

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